Overt Cardiac Disease: acute coronary syndrome (STEMI, NSTEMI, unstable angina), history of surgical and/or percutaneous coronary revascularization, or evidence of silent myocardial infarction at EKG, echocardiography, myocardial scintigraphy/SPECT or cardiac MRI.
Subclinical Cardiac Disease: in patients at veri high CV risk (SCORE2-D>20%) evidence of at least one plaque ≥50% at coronary angio-CT/coro-CT, a CAC score >100 Agaston, or a positive stress test (echo, ECG, or nuclear imaging stress test)
Overt Cerebrovascular Disease: hystory of ischemic stroke or carotid revascularization
Subclinical Cerebrovascular Disease: evidence of at least one carotid plaque ≥ 2 mm and/or stenosis ≥ 30% detected by echocolordoppler
Overt Peripheral Artery Disease: any amputation due to atherosclerotic-related ischemia or any peripheral revascularization, either previously performed or planned
Subclinical Peripheral Artery Disease: evidence of left and/or right ABI <0.9
Overt Diabetic Kidney Disease: evidence of ≥50% e-GFR reduction with respect to the predicted-for-age eGFR (p-eGFR= 100-(age-50)*0.94) and/or macroalbuminuria (urinary albumin to creatinine ratio, ACR, ≥300 mg/g)
Subclinical Diabetic Kidney Disease: evidence of 25-49% e-GFR reduction with respect to the p-eGFR and/or microalbuminuria, defined as ACR 30-299 mg/g
Overt Diabetic Retinopathy: evidence of any type of proliferative retinopathy/high-risk non-proliferative retinopathy, or any previous treatment for diabetic retinopathy
Subclinical Diabetic Retinopathy: low/middle-risk non-proliferative retinopathy or background retinopathy
Overt DPN: MNSI >4
Subclinical DPN: MNSI 2.5–4
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